Nacre-derived range
Bionacre®
Bone Graft.
Our nacre-derived bone substitute programme, developed for filling bone defects in dental surgery.
In development · late preclinical stage
Explore the Bionacre® programmePortfolio & development
Biomaterials.
Multiple opportunities.
Two distinct dental ranges: nacre-derived Bionacre® and Ostenova, which brings together a porcine-derived bone substitute and collagen membranes.
Our dental ranges
Bionacre® & Ostenova.
Two distinct ranges.
Bionacre® is developed from nacre. Ostenova brings together a porcine-derived bone substitute and collagen membranes. Each product follows its own pathway.
Bionacre®
Bone substitute & membranes
Ostenova.
A dental range in its own right.
Coming soon
Granules · 0.5 cc0,25–1,0 mm 
Granules · 2.0 cc1,0–2,0 mm 
Syringe · 0.5 cc0,25–1,0 mm
Bone substitute
A porcine-derived bone substitute within the Ostenova range.
Contact the product teamLaunch planned for late 2026
Collagen membranes
Resorbable porcine collagen membranes in three sizes.
Discover the membranes
BIONACRE® BONE GRAFT / PROGRAMME STATUS
From preclinical development
to the next milestones.
Late preclinical stage
Bionacre® Bone Graft is in the final stage of preclinical development.
Clinical investigation
Applications to conduct a clinical investigation in Europe are being prepared.
Planned 510(k) submission
A submission to the FDA is planned for early 2027. This milestone is prospective.
Status communicated by MEGA BIOPHARMA in September 2026. Submitting a dossier does not constitute market authorisation.
Bionacre® platform opportunities
From bone
to cartilage.
One technology foundation, several research directions. Each application requires its own development and assessments.
Orthopaedics
Bone repair & fixation
Machined components, compact forms and potential applications in extremities, trauma and spine.
Research directionCartilage
Injectable formulations
Nacre-derived materials to explore cartilage and osteochondral repair, including injectable formats.
Research directionMaxillofacial surgery
New reconstruction needs
Opportunities to evaluate with clinical and industrial partners.
Research directionAn application already on the market
Blue Skincare
Alongside our bone-regeneration programmes, our expertise in nacre has led to a dermo-cosmetic range already on the market.
Visit the e-shop ↗Customer satisfaction
4.9/5
More than 900 verified reviews reported by Blue Skincare: a rating that reflects strong satisfaction with the skincare products.
Read customer reviews ↗Rating displayed on the Blue Skincare website, accessed 1 October 2026. Feedback on cosmetic skincare products.Let’s discuss your project