01Skin barrier
Filaggrin
At 24 hours · delipidated skin
- Formula with 0.5%
- +22%
- Formula with 2%
- +51%
Change in the area where filaggrin, a skin barrier protein, is detected.
BIO-EC · 22E5751 · 2022
p < 0.01 · vs untreated control
SKIN RESEARCH
Skin research.
From fractions to formulations.
Translational research into the skin barrier and tissue repair, building on our dermo-cosmetic experience.
NACRE ACTIVE-NACR-45®
Understand.
Formulate.
Evaluate.
We study nacre fractions in formulations for the skin.
This work uses NACRE ACTIVE-NACR-45® technology, referred to below as NACR-45®. Laboratory studies assess the formulations; Blue Skincare is our cosmetic skincare activity.
Discover Blue Skincare ↗EX VIVO RESEARCH · 2022–2023
Skin, observed
in the laboratory.
Human skin samples maintained in the laboratory: this is the basis of ex vivo studies. Two models assess formulations containing 0.5% and 2% NACR-45® for skin barrier and tissue repair markers.
02Dermal matrix
Collagen I
At day 7 · area around the wound
- Formula with 0.5%
- +36%
- Formula with 2%
- +41%
Change in the area where collagen I is detected in the dermis around the wound.
BIO-EC · 22E5997 · 2023
p < 0.01 · vs untreated control
03Repair model
Fibronectin
At day 3 · wounded area
- Formula with 0.5%
- +56%
- Formula with 2%
- +67%
Change in the area where fibronectin, an extracellular matrix protein, is detected.
BIO-EC · 22E5997 · 2023
p < 0.05 · vs untreated control
Relative changes in immunostained areas compared with untreated controls in the same model. These experimental findings concern the tested formulations; they do not establish clinical benefit in patients.
Models and sources
Skin barrier
BIO-EC study 22E5751: 51 explants from one donor, including 21 delipidated explants. Assessment after topical application of two formulations. The values shown concern filaggrin staining at 24 hours in delipidated explants.
Tissue repair
BIO-EC study 22E5752: 42 explants from one donor, including 21 with mechanical wounds. Additional analysis of immunostaining in January 2023 (22E5997), using the 2022 samples.
One donor per model; analysed images are technical measurements, not independent participants. Comparisons concern formulations and untreated controls, without isolating the effect of nacre from that of the formula.
- BIO-EC 22E5751 · technical phase completed 23 August 2022, report signed 5 October 2022.
- BIO-EC 22E5752 · report dated 21 October 2022.
- BIO-EC 22E5997 · supplement dated 23 January 2023, pages 8 and 10.
- NACR-45® technical dossier, FI.AR.G.035, V4, approved 30 January 2025: synthesis of the preceding studies.
An application already on the market
Blue Skincare
Alongside our bone-regeneration programmes, our expertise in nacre has led to a dermo-cosmetic range already on the market.
Visit the e-shop ↗Customer satisfaction
4.9/5
More than 900 verified reviews reported by Blue Skincare: a rating that reflects strong satisfaction with the skincare products.
Read customer reviews ↗Rating displayed on the Blue Skincare website, accessed 1 October 2026. Feedback on cosmetic skincare products.Let’s discuss your project