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Bone regeneration · Dental programme

Bionacre®Bone Graft.

Nacre.
A new horizon for bone.

Contact the team

Late preclinical stage

View of Bionacre® particles published by MEGA BIOPHARMA
Bionacre® Bone GraftParticle view
MEGA BIOPHARMA
Explore the programme

From material to medical device

Supporting physiological
bone regeneration.

Restoring bone volume is a key need in many dental procedures. Bionacre® Bone Graft, our lead programme, explores an approach combining scaffold function, biological interaction and progressive remodelling. The ambition is to create conditions favourable to new bone formation.

Marine origin — MEGA BIOPHARMA

It starts
with nacre.

Nacre from Pinctada maxima is the starting material for our research. A marine origin, opening new research paths in bone regeneration.

The concept under investigation

From scaffold
to regeneration.

01

Placement

Granules designed to occupy the bone defect and provide a scaffold for repair.

02

Biological interaction

The interface with cells, proteins and fluids is studied to understand the tissue response.

03

Progressive remodelling

Assessments track how the material evolves and resorbs over time.

04

Bone formation

The objective is to support new bone formation and progressive replacement of the biomaterial.

This sequence describes the development objective and the processes assessed in preclinical studies. It does not establish a demonstrated clinical benefit of Bionacre® Bone Graft.

Bionacre® Bone Graft in detail

Understand
the programme.

01 / Dental surgery

Five applications.
One research programme.

Defined clinical situations guiding Bionacre® Bone Graft development.

  1. Schematic cutaway: granules in an extraction socket between two teeth.
    01

    Socket preservation

    Socket filling after extraction, to investigate preservation of alveolar ridge dimensions.

  2. Schematic cutaway: bone defect filling alongside a dental implant.
    02

    Peri-implant defects

    Filling alveolar bone defects associated with dental implant placement.

  3. Schematic cutaway: intrabony defect alongside the root of a retained tooth.
    03

    Periodontal defects

    Intrabony defects around natural teeth.

  4. Schematic cutaway: granules added along the contour of a narrow alveolar ridge.
    04

    Ridge augmentation

    Horizontal or vertical bone volume augmentation before or during implant placement.

  5. Schematic maxillary cutaway: granules between the bony sinus floor and elevated sinus membrane.
    05

    Sinus floor augmentation

    Bone volume augmentation in the posterior maxilla in preparation for implant placement.

Schematic illustrations · Teal: illustrated grafting area.These are target applications for Bionacre® Bone Graft development, not authorised indications.

Discuss the programme

Let’s stay
in touch.

Questions about target applications, available data or next steps? Contact our team.

Ask about Bionacre® Bone Graft

MEGA BIOPHARMA

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